Gender Affirmation
We carry a generic version of the long-acting male hormone (Nebido).
The price is approximately half that of the original product, making it very affordable. Please consider it.
We keep in stock all preparations required for hormone therapy, regardless of the preparation.
If you have any concerns, please contact us on our LINE.
We provide Gender Affirmation so that we can offer holistic support to people with gender incongruence (GI: Gender Incongruence).
We participate in the NPO Kansai GIC Network and in gender change assessment conferences, and we provide care in line with the “Guidelines for the Diagnosis and Treatment of Gender Incongruence” while coordinating with psychiatry, obstetrics and gynecology and other departments within the network.
A doctor specializing in Gender Affirmation conducts the consultation, and you can discuss appropriate hormone treatment and future plans with them, so please rest assured.
Regarding Gender Affirmation, we do not provide telephone consultations.
Patients who wish to receive care at our clinic are asked to visit in person.
After the consultation, if the specialist determines that hormone treatment is appropriate, hormone treatment and testing can be carried out the same day.
Please consult with a doctor for more details.
We accept Gender Affirmation (including first visits) on essentially all business days.
Dr. Ikebukuro’s clinic days are as follows.
Saturday, October 24, 2026 14:00-20:30
Sunday, October 25, 2026 10:00-11:30
If you have any questions about Gender Affirmation, please contact us through our official LINE.
Please select the section to jump to.
Note that the prices indicated in this page are all inclusive of tax.
What is Gender Affirmation?
The tests and treatments we can provide are as follows.
Counseling and hormone therapy are self-pay only.
Counseling
For people experiencing gender dysphoria, we listen carefully to your concerns and talk with you about treatment and the process going forward.
We also accept treatment consultations from people already undergoing treatment who have concerns about their future care.
We can discuss treatment plans, but we do not provide diagnoses of gender incongruence.
Hormone Therapy
Treatment for people with GI/GD includes “hormone-based treatment” and “gender-related surgery.”
We conduct a thorough medical interview and consultation and support you so that hormone therapy can be carried out safely.
If you wish to receive physical treatment such as “mastectomy” or “gender affirmation surgery,” we will select a clinic together with you as far as possible and provide a referral.
For transgender men (FTM), we provide male hormone therapy, and for transgender women (MTF), we provide female hormone therapy.
Carrying out hormone therapy on your own judgment is dangerous, so please be sure to consult us.
Regular Testing Accompanying Hormone Therapy
Once hormone replacement therapy is started, you become more prone to a variety of comorbid conditions such as liver dysfunction, kidney dysfunction, dyslipidemia, diabetes, polycythemia, thrombosis and osteoporosis.
We can perform testing for the following.
We check liver function, kidney function, dyslipidemia, uric acid levels, hormone levels, etc. Based on the test results, we adjust the hormone dosage as needed.
Thrombosis is a risk as a complication accompanying hormone therapy.
In addition to blood tests, we can perform lower-limb ultrasound, cardiac echo and carotid echo if necessary, and provide comprehensive care including assessment of cerebral infarction and myocardial infarction.
Hormone Therapy
We summarize the options and side effects for hormone therapy.
Hormone Therapy Options
Main indications:
AFAB (Assigned female at birth) transgender people, FTM (Female to male) people, non-binary people, etc.
Medication options:
Injectable: short-acting male hormone (Testoviron), long-acting male hormone (Nebido generic)
Topical: Cernos Gel, Glowmin, 1UP Formula
Oral: Cernos Capsule
Main effects:
Redistribution of body fat, increased muscle strength, increased facial and body hair, deepening of the voice, cessation of menstruation, clitoral enlargement, vaginal atrophy, oily skin and acne, androgenetic alopecia (Androgenetic Alopecia: AGA)
Main side effects:
Polycythemia, abnormal liver function values, cardiovascular disease, hypertension, etc.
Testoviron, a short-acting male hormone preparation, has the same active ingredient as Enarmon Depot and Testinon Depot.
Main indications:
AMAB (Assigned male at birth) transgender people, MTF (Male to female) people, non-binary people, etc.
Medication options:
Topical: L’Estrogel
Patch: Estrana Tape
Oral: Progynova (estradiol (17β-estradiol) preparation)
Injectable: Progynon Depot
Main effects:
Breast development, changes in body shape such as fat deposition, decreased muscle strength, softening of the skin and reduced sebum, decline in sexual function such as reduced libido and reduced erections, testicular atrophy and loss of spermatogenic function, etc.
Main side effects:
Thrombosis, cardiovascular disease, gallstones, hyperprolactinemia, dyslipidemia, breast cancer (long-term risk), etc.
Conjugated estrogens (e.g. Premarin) have been noted to make blood concentration assessment difficult and to carry risks such as thrombosis.
The guidelines propose avoiding conjugated estrogens where an estradiol (17β-estradiol) preparation can be used.
Main indications:
AMAB (Assigned male at birth) transgender people, MTF (Male to female) people, non-binary people, etc.
Medication options:
Oral: spironolactone
Main effects:
Reduction of testosterone (male hormone), breast development and breast swelling, reduced erections and reduced libido, reduction of body hair, etc.
Main side effects:
Frequent urination, low blood pressure, low mood, and arrhythmia, general fatigue and weakness accompanying electrolyte abnormalities (hyperkalemia, hyponatremia, etc.), etc.
Main indications:
AMAB (Assigned male at birth) transgender people, MTF (Male to female) people, non-binary people, etc.
Medication options:
Oral: oral micronized progesterone (natural type, Micronized progesterone)
Main effects:
It is sometimes added in the hope of breast development, but the effect varies from person to person. Changes in the sensitivity of the breasts and nipples may be seen.
Main side effects:
Drowsiness and fatigue, dizziness, headache, mood swings (such as low mood), breast pain and breast/nipple hypersensitivity, nausea and stomach discomfort, abdominal bloating, swelling, etc.
Some synthetic progestins (e.g. medroxyprogesterone acetate) have been reported to increase the risk of breast cancer, cardiovascular events and thrombosis, so we do not use them.
Testing Required for Hormone Therapy
During hormone therapy, you become more prone to a variety of comorbid conditions such as liver dysfunction, kidney dysfunction, dyslipidemia, diabetes, polycythemia, thrombosis and osteoporosis.
It is also necessary to measure hormone levels regularly. Hormone replacement therapy that exceeds permissible levels can sometimes cause fatal complications.
We recommend performing blood sampling and hormone measurement when starting and continuing hormone replacement therapy.
Blood count, liver function, kidney function, electrolytes, uric acid, CK, TG, LDL, HDL, blood glucose, HbA1c
In addition to the above, the following hormone tests can be performed.
Before oophorectomy: estrogen, testosterone
After oophorectomy: (estrogen), testosterone
In addition to the above, the following hormone tests can be performed.
Before orchiectomy: estrogen, testosterone
After orchiectomy: estrogen, (testosterone)
We recommend measuring prolactin once a year.
Gender Affirmation is basically provided on a self-pay basis only, but depending on the patient’s underlying conditions, blood tests and the like may in some cases be performed under insurance coverage.
Please contact a doctor for more details.
Prices
Gender Affirmation is in principle provided as self-pay care.
Self-pay fees are calculated according to the price calculation below.
[Total Price] = [Consultation fee] + [Testing fee] + [Medication fee]
Consultation Fee
The consultation fee differs between first visits and follow-up visits.
Anyone who has visited our clinic even once, whether under insurance coverage or self-pay, is charged the follow-up visit fee.
First visit fee: 2,500 JPY
Follow-up visit fee: 1,000 JPY
Testing Fee
Testing fees are as follows.
| Type of test | Price (JPY) | Test results* |
|---|---|---|
| Hormone therapy blood sampling package | 3,000 | after 2–3 days |
| Testosterone + estrogen | 2,000 | after 4–5 days |
| Testosterone | 1,500 | after 4–5 days |
| Free testosterone | 1,500 | after 4–5 days |
| Estrogen | 1,500 | after 4–5 days |
| D-dimer (assessment of thrombosis risk) | 1,500 | after 2–3 days |
| LH | 1,500 | after 4–5 days |
| FSH | 1,500 | after 4–5 days |
| Prolactin | 1,500 | after 4–5 days |
| Chromosome test*2 | 33,000 | after 4–6 weeks |
*The number of days until test results are reported is a guide counted from the “testing start date.” For samples taken after the evening on the day, or on Sundays, public holidays or the year-end and New Year period, the next business day becomes the “testing start date.” For self-pay care, results can be checked by email.
*2 This is by appointment only. If you would like it, please contact us via LINE.
Treatment Fee
The prices of hormone therapy are as follows.
We carry a generic version of the long-acting male hormone (Nebido).
The price is approximately half that of the original product, making it very affordable. Please consider it.
| Type | Preparation | Price (JPY) |
|---|---|---|
| Short-acting male hormone | Testoviron 100mg | 2,500 |
| Testoviron 250mg | 3,500 | |
| Long-acting male hormone | Nebido generic (Cernos injection) |
18,000* |
| Nebido generic oral medication (Cernos capsule) |
1 box: 5,000/30 tablets 3 boxes: 14,000/90 tablets 6 boxes: 27,000/180 tablets |
|
| Male hormone topical medication | Cernos Gel (1% testosterone undecanoate topical skin preparation) |
4,000–9,000/month*2 |
| Glowmin (1% testosterone topical skin preparation) |
4,100 | |
| 1UP Formula (5% testosterone topical skin preparation) |
Self-pay prescription fee: 2,200 (+ medication price)*3 |
|
| Short-acting female hormone | Progynon Depot 10mg | 2,000 |
| Progynon Depot 20mg | 3,000 | |
| Female hormone topical medication | L'Estrogel | 1 bottle: 4,300 2 bottles: 6,200 3 bottles: 8,100 |
| Female hormone patch | Estrana Tape | 14 patches: 2,300 28 patches: 4,500 42 patches: 6,500 56 patches: 8,500 84 patches: 12,500 |
| Female hormone oral medication | Progynova (2mg) |
3,500/28 tablets 9,000/84 tablets 16,000/168 tablets 30,000/336 tablets 43,000/504 tablets |
| Anti-male hormone preparation (anti-androgen agent) |
Spironolactone | 50mg: 2,500/30 tablets 100mg: 5,000/30 tablets 150mg: 7,500/30 tablets 200mg: 10,000/30 tablets |
| Progesterone preparation | Oral micronized progesterone (200mg) |
4,000/30 tablets 11,000/90 tablets 20,000/180 tablets |
*The price of hormone measurement is included.
*2 The amount used and the amount prescribed differ according to each patient’s individual situation. Please consult with a doctor at your consultation for details.
*3 For 1UP Formula, you pay a self-pay prescription fee of 2,200 JPY at our clinic, and pay the medication price separately at a specialized pharmacy (approx. 12,100 JPY).
Testoviron, a short-acting male hormone preparation, has the same active ingredient as Enarmon Depot and Testinon Depot.
Types of Consultation and the Process
If you would like a first consultation, please visit us on a consultation day for the “Gender Affirmation (First Visit)” clinic.
As with our other departments, Gender Affirmation gives priority to appointments.
Visiting without an appointment is expected to involve a long wait, so please make an appointment and fill in the medical questionnaire in advance.
Appointment
Please book from “Gender Affirmation” on our clinic’s website.
For “Gender Affirmation (First Visit),” a doctor specializing in Gender Affirmation examines every patient.
For our Gender Affirmation, first visits are accepted only on the “Gender Affirmation (First Visit)” dates.
Hormone treatment from the second visit onward can be administered on dates other than those listed below. Please book from “Gender Affirmation (Follow-Up)” on the appointment site.
Filling in the Medical Questionnaire
After completing your booking, please click the link shown at the bottom of the booking confirmation email and fill in the medical questionnaire.
Visiting on the Day
Please come to the clinic at your appointment time on the day. We will give you a number at reception and call you by that number for testing, payment and so on.
Medical Interview and Consultation with a Doctor
Based on your medical questionnaire, we provide appropriate advice, testing and treatment.
Health Check
We provide health checks for people of every gender.
We can also discuss matters such as how your name and gender are shown, so please feel free to visit us with peace of mind.
The health checks we provide are as follows. Health check results will be sent to you by email.
Price: 6,000 JPY (consultation fee included)
Description: This is the minimum necessary periodic health check within the periodic health checks required by the Industrial Safety and Health Act. It is for people under 39 years of age who are not 20, 25, 30 or 35 years old.
Time required: approx. 30 minutes
Contents: doctor’s consultation, physical measurements, urine test, hearing test, vision test
Results: sent by email within 1 week (if you would like them posted, we can arrange this for +500 JPY. If you would like the results prepared in English, we can arrange this for +5,500 JPY)
Pre-Employment Health Check
Price: 10,000 JPY (consultation fee included)
Description: This is the periodic health check required by the Industrial Safety and Health Act. Please choose this if you need a chest X-ray (those aged 40 and over, or those under 40 who are 20, 25, 30 or 35 years old).
Time required: approx. 45–60 minutes (the chest X-ray may be taken on a later date)
Contents: doctor's consultation, physical measurements, blood test, urine test, hearing test, vision test, electrocardiogram, chest X-ray examination*
Results: sent by email within 1 week after the chest X-ray is taken (if you would like them posted, we can arrange this for +500 JPY. If you would like the results prepared in English, we can arrange this for +5,500 JPY)
Price: 13,000 JPY (consultation fee included)
Description: This is the minimum necessary health check required by the Industrial Safety and Health Act before and after being posted overseas.
Time required: approx. 45–60 minutes (the chest X-ray may be taken on a later date)
Contents: doctor’s consultation, physical measurements, blood test, urine test, hearing test, vision test, electrocardiogram, chest X-ray examination*
Results: sent by email within 1 week after the chest X-ray is taken (if you would like them posted, we can arrange this for +500 JPY. If you would like the results prepared in English, we can arrange this for +5,500 JPY)
*The imaging is done at our Partnered Clinic (approx. 2 minutes on foot). There is no payment of any kind at the Partnered Clinic.
Acne Treatment and Prevention
Acne is a condition that troubles many people across a wide range of ages and regardless of gender.
It is worsened by a variety of influences such as lifestyle habits, diet, hormone therapy, cosmetics and skincare products.
We can provide acne treatment and prevention for people of every gender.
Stubborn acne during testosterone therapy in trans men can also be improved and prevented without discontinuing testosterone therapy.
For acne in trans women, estrogen plus anti-androgen therapy may reduce sebum and ease the acne.
If you are undergoing hormone therapy, please tell your doctor.
Physician; obstetrics and gynecology specialist certified by the Japan Society of Obstetrics and Gynecology; certified physician of the Japanese Society of GI (Gender Incongruence).
In charge of Gender Affirmation at Idaten Clinic and Personal Health Clinic. Has provided care to more than approximately 3000 transgender people over 2 years, and specializes in transgender healthcare and sexual healthcare.